Services
Custom Oligos
Specializing in the synthesis of
custom DNA and RNA oligonucleotides.
Custom Oligos
Since 2006, Oligo Factory has specialized in producing custom DNA and RNA oligos with a delivery scale of 25mg up to the kilogram range.
Our solid-phase synthesis approach provides outstanding quality and purity for oligos with 200 bases or fewer. With our 100% US-based primary supply chain, we have shipped in six weeks or less every single order since January 2022.
TIP: for oligos of 80 bases or fewer, 25mg is usually at least 1 umol of material
What We Build
DNA
Our team uses in-house-developed synthesizers to produce your DNA faster and with higher initial purity than the competition, even for complex sequences with poly-base strings or unusually high or low GC content. We also specialize in modified DNA, from probes to spacers to inverted bases.
RNA
Our synthesis team has deep expertise synthesizing both unmodified and modified RNA. We have experience making RNA of all shapes and sizes, from unmodified strands of RNA to highly modified ASOs with 2’OMe and 2’F modifications to guide RNAs up to and over 100 base pairs in length.
Beyond
From fluorescent probes to PTO or LNA backbones to bioorthogonal reactive sites, we have experience with a diverse range of modifications for applications throughout therapeutics, diagnostics, functional genomics, NGS, qPCR, and synthetic biology.
We’ve synthesized oligos with almost every modification. Click here to see some of the common modifications we’ve produced for customers.
Synthesis & Purification
Proprietary Synthesis Technology
Our third-generation in-house built solid-phase oligo synthesizer runs twice as fast as commercially-available synthesizers, provides outstanding initial purity, and is designed to work most efficiently at scale.
Purification
Our purification team uses several industry approved purifications via HPLC – both reverse-phase and ion-exchange. We also can develop in-house options per customer requirement to maximize yield and purity needs. Purity specifications are set by the customer, but we routinely manufacture to a purity of 90%+, 95%+, or higher as needed.
Analysis
The Oligo Factory Certificate of Analysis (CoA) comes standard with both HPLC purity analysis and LC-MS molecular weight confirmation chromatograms. We also provide additional services and analysis, such as endotoxin testing, upon request.
Consultation & Process Development
Our scientists are here to assist from start to finish with your oligo synthesis project. We routinely assist our customers and partners with synthesis and purification protocol design and transfer as well as any analytical needs you may have.
To speak to one of our scientists or get a quote for your oligo synthesis project, please click the link below.
Address:
56 Boynton Rd, Holliston, MA 01746
Contact:
Phone: (508) 275-3561
Email: Info@oligofactory.com
