Oligo Factory is a leader in DNA/RNA oligonucleotide synthesis at scale. We have expertise in modified and natural DNA/RNA synthesis of all lengths. 

Common Custom Oligos:

  • Fully Phosphorothioated Oligonucleotides (PTO)
  • Natural and Modified RNA Oligonucleotides
  • Antisense Oligonucleotides
  • Chimeric Oligonucleotides
  • Large Scale PCR Oligonucleotides
  • Dual-labeled Probes
  • and many more…

Common Modifications

(But not limited to):

  • 2′-0Me RNA and 2′-Fluoro RNA
  • C3-Amino, C6-Amino, C12-Amino
  • C18-Spacer, C9-Spacer, C3-Spacer, PEG
  • FAM, ROX, Cy3, Cy5, BHQ, Alexa
  • C3-Thiol, C6-Thiol
  • LNA (A/C/G/U), BNA
  • 5′-phosphate
  • 5′-Biotin, 3′-Biotin, dT-Biotin
  • Inverted dT
  • and many more…

Special Services:

  • Annealing
  • Aliquoting (by mass)
  • Endotoxin Testing
  • Additional LCMS analysis

*We’ve synthesized oligos with almost every modification. Please inquire about other oligos and modifications not seen here.

Competitive Advantages

Our Service and Products are built to serve all the DNA/RNA synthesis markets and applications. From synthetic biology to qPCR to functional genomics and therapeutics, we treat every custom product with ultimate care and attention to ensure results for your research or products.

Custom Oligo Expertise

Our world-class DNA synthesis experience and insight enables us to tackle ANY challenging synthesis or oligo product needs

Reproducible Quality

Our proprietary synthesis and purification systems deliver high-quality oligos at the purest levels available from your first research experiment to your production needs


We provide mass production of oligos with high purity from milligram to gram quantities at a price that allows your business to grow 

Excellent Technical and Customer Support

We believe in a partnership with all our customers at a project level – from custom modifications to unique purification needs and quality assessments. Our #1 driver is understanding your needs and desired results

Our customer-centric approach + oligo synthesis expertise enable us to deliver at scale at lower prices

2023 Pricing Estimates

DNA (Unmodified)Price
25 mg$2,525
100 mg$2,775
250 mg$3,250
500 mg$3,725
1 Grams$5,025
5 Grams$11,200
10 Grams$20,580
100 Grams$178,190
Greater than 200 gPlease Inquire
Kilogram +Please Inquire
RNA (Unmodified)Price
25 mg$4,850
100 mg$6,925
250 mg$11,150
1 Grams$18,895
2 Grams$32,250
Greater than 2 gPlease Inquire

NOTE: The prices above are estimates. Each quote request proceeds through a custom quoting process.

Get a Custom Quote Today

56 Boynton Rd, Holliston, MA 01746

Phone: (508) 275-3561