RNAi
GMP oligos for RNAi-based therapies
OVERVIEW
Revolutionizing Gene Silencing
RNA interference (RNAi) is a powerful biological process that utilizes short, non-coding RNA molecules (microRNAs) to suppress gene expression through targeted neutralization or degradation of messenger RNA (mRNA). Therapeutic development centered on the use of RNAi to silence or suppress gene activity requires the use of small RNA molecules with high specificity and stability to ensure potency, minimize off-target effects, and ensure efficient delivery into the cell.
Oligo Factory specializes in producing GMP RNAi molecules, including small interfering RNAs (siRNA), dicer-substrate small interfering RNAs (DsiRNA), microRNAs (miRNA), and aptamers with exceptional purity and yield using our proprietary NANDA synthesis platform. Our advanced manufacturing process, combined with rigorous quality control measures, ensures that our customers receive RNAi products that meet the highest standards for research and therapeutic applications.
Discover how Oligo Factory leveraged expertise in post-synthesis conjugation to help a therapeutics company with production of a siRNA-GalNAc conjugate, reducing costs and ensuring scalability in this case study.
Benefits
Your Partner at Every Phase of Therapeutic Development
We are committed to continuous innovation in RNAi design and flexible, scalable manufacturing to support projects from discovery to commercialization.
- Custom Synthesis: We specialize in producing siRNA, miRNA, and modified RNAi molecules tailored to your specific requirements.
- Scalable Production: Our scalable GMP manufacturing services ensure the delivery of consistent, high-quality products from milligram quantities for early research to gram-scale production for preclinical and clinical studies.
- GMP-compliance: We meet ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients (APIs), ensuring the highest standards for clinical-grade oligos.
- Expert Support: Our experienced team will guide you from design concept to commercialization of your RNAi molecules, working with you at every phase of the therapeutic development pipeline.
Applications
Pushing the Boundaries of Medicine
From investigational research to the development of novel therapies, our high-quality RNAi molecules support innovation.
- miRNA research for cancer therapeutics
- Development of siRNA-based drugs for genetic disorders
- Neurodegenerative disease studies
- Antiviral therapy development
- RNAi screens for drug target identification
- Functional genomics screening
Why Therapeutics Manufacturers Partner with Oligo Factory
Partnership
Our team supports you at every phase of the product lifecycle, from discovery to clinical application.
Scalable Production
By working with a single supplier that can scale production as your needs grow, you can eliminate the risks associated with technical transfer.
Rapid delivery
To help our customers meet tight timelines, we deliver your custom oligos within 4-6 weeks.
Ready to scale up your RNAi applications?
Address:
56 Boynton Rd, Holliston, MA 01746
Contact:
Phone: (508) 275-3561
Email: Info@oligofactory.com
