Gapmers
Bridging the Gap in Antisense Therapeutics
OVERVIEW
Advancing Targeted Gene Modulation
Gapmers are specialized antisense oligonucleotides (ASOs) designed with a central DNA “gap” flanked by chemically modified nucleotides. This unique structure enhances target binding affinity, nuclease resistance, and RNase H recruitment, making gapmers powerful tools for gene silencing and modulation. As the demand for precise gene therapies grows, high-quality gapmer production becomes increasingly critical for therapeutic development and clinical applications.
Oligo Factory leverages finely-tuned solid phase synthetic chemistry and extensive experience to produce superior gapmers at scale. Our advanced NANDA Series synthesizers enable precise control over complex modifications and ensure exceptional purity, even for challenging sequences.
Benefits
Elevating Your Gapmer Development
At Oligo Factory, we specialize in synthesizing high-quality gapmers tailored to your specifications.
- Customized design: We work closely with you to optimize gapmer sequences and modifications for maximum efficacy and stability.
- Scalable production: From milligram quantities for early research to kilogram-scale production for clinical trials, we support your entire product lifecycle.
- Superior purity: Our closed-system single oligonucleotide synthesis workflow routinely achieves purity levels of 90%+, 95%+, or higher based on customer requirements.
- Rapid turnaround: With streamlined processes, production to delivery for gapmer orders within 4-6 weeks.
- Regulatory compliance: We meet ICH Q7 Good Manufacturing Practice guidelines for APIs, ensuring the highest standards for clinical-grade oligos.
Applications
Powering Therapeutic Breakthroughs
Our high-quality gapmers support innovative research and development across multiple therapeutic areas.
- Rare genetic disorder treatments
- Cancer immunotherapies
- Neurodegenerative disease interventions
- Metabolic disorder therapies
- Antiviral drug development
- Cardiovascular disease treatments
Why Gapmer Developers Partner with Oligo Factory
Partnership
Our team partners with you in a flexible, custom manner from initial design to scale-up and manufacturing.
Scalable Production
Our flexible production capabilities allow seamless scaling from research quantities to clinical trial volumes.
Rapid delivery
Controlled synthesis technology and rigorous QC measures ensure delivery of high-purity gapmers that meet your timelines.
Ready to advance your gapmer therapeutic program?
Address:
56 Boynton Rd, Holliston, MA 01746
Contact:
Phone: (508) 275-3561
Email: Info@oligofactory.com
