Antisense Oligonucleotides (ASOs)
Precision-engineered oligonucleotides for targeted therapies
OVERVIEW
Advancing ASO Technology
Antisense oligonucleotides (ASOs) are short, synthetic single-stranded DNA or RNA molecules designed to selectively bind to messenger RNA (mRNA) and modulate gene expression. This binding can either block the translation of the mRNA into protein or trigger its degradation, effectively “silencing” the target gene. This mechanism of action makes ASOs invaluable in treating a wide range of diseases, from rare genetic disorders to cancers, therefore, ASOs must be manufactured with high purity and accuracy to ensure specificity. ASOs may also require the addition of complex modifications to enhance binding and stability for improved efficacy.
Oligo Factory produces high-quality ASOs at scale that meet your exact specifications. Our proprietary NANDA synthesis platform enables us to produce ASOs with superior purity, yield, and consistency, even for complex sequences and modifications, that meet the demands of clinical applications.
Benefits
Your Trusted Partner in ASO Manufacturing
Our approach to ASO synthesis combines cutting-edge technology with unparalleled expertise.
- Solid-Phase Synthesis: We utilize advanced solid-phase synthesis techniques to produce ASOs of outstanding quality and purity.
- Customization Capabilities: We offer a wide range of modifications including 2′-OMe, 2’-MOE, 2’F, and phosphorothioate linkages and can assist with complex ASO designs, including those with LNA flanks.
- Scalable Production: From 25mg quantities for early research to kilogram-scale production for clinical trials, our facilities are equipped to meet your needs at every stage of development.
- GMP Compliance: We meet ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients (APIs), ensuring the highest standards for clinical-grade oligos.
Applications
Furthering Next-Generation Therapies
Our processes ensure high purity, accuracy, and yield to accelerate ASO therapeutic development.
- Personalized therapies for rare genetic disorders
- Antiviral treatments
- Neurodegenerative and neuromuscular disease management
- Cancer therapeutics
- Cardiovascular and metabolic disease interventions
- Enhancing the efficacy of existing treatments through combination therapies
Why Therapeutics Manufacturers Partner with Oligo Factory
Expert Support
You will receive dedicated support from experienced scientists throughout your project.
Unmatched Quality
We utilize controlled oligo manufacturing and comprehensive quality control measures, including HPLC and LC-MS analysis, to ensure delivery of high purity ASOs.
Rapid Turnaround
With streamlined processes from synthesis to purification, you can expect orders to arrive in 4-6 weeks.
Ready to advance your ASO program?
Address:
56 Boynton Rd, Holliston, MA 01746
Contact:
Phone: (508) 275-3561
Email: Info@oligofactory.com
