Custom DNA & RNA Oligonucleotides
Quality. Speed. Scale.
Your trusted oligo partner from discovery through clinical development
Get a Custom Quote Today
Meeting the Demands of Therapeutic, Diagnostics & Life Science Applications
- Quality: ICH Q7 GMP for APIs, ISO 13485:2016 for diagnostics and ISO 9001 for RUO
- Speed: Production to delivery in 4-6 weeks
- Scale: mg to kg yields support late-stage discovery through clinical trials
Therapeutics
Our outstanding turnaround time and delivery at-scale, without sacrificing quality, enables therapeutics manufacturers to get to market fast.
CRISPR, gRNA
siRNA, dsiRNA
ASO
Aptamers
Custom Oligo Offerings
We offer a wide menu of commercially available and custom modifications. Click here to see a list of commonly used modifications.
Antisense Oligonucleotides
Single-stranded RNA or DNA for targeted therapies and gene silencing
siRNA & miRNA
Double-stranded RNA or chimeric molecules for gene silencing and expression modulation
Aptamers
Single-stranded RNA or DNA designed to bind tightly to protein targets in therapeutic and diagnostic applications
Guide RNAs
For RUO or therapeutic applications, guide RNAs are a key component of CRISPR-based gene editing workflows
Primers and Adapters
For RUO and diagnostic applications, PCR primers, NGS P5/P7 primers, and library prep adapters
Fluorescent Probes
Single- and dual-labeled probes are available with all common fluorophores and quenchers
The Oligo Factory Experience
01
Custom Sequence Submission
Submit your sequence through our simple online portal.
02
Pre-Order Consultation
A scientist assigned to work with you directly throughout your order will schedule a time with you to discuss your custom order.
03
Order
Finalization
After your consultation, we will finalize your order and immediately begin production.
04
Production & Delivery
Your oligo will be produced entirely in-house by our expert team utilizing our proprietary oligo synthesis technology.
05
Post-Delivery Consultation
After your custom oligo order is delivered, your Oligo Factory scientist will check in to ensure everything worked out as expected.

about oligo factory
Founded in 2006 in Holliston, Massachusetts by oligo synthesis technology innovators, our mission is to provide high-quality custom DNA and RNA oligos at superior speed and scale (mgs to kgs) for therapeutic, diagnostic and life science applications.
The Oligo Factory team is made up of highly skilled chromatographers, synthesis chemists, instrumentation engineers and commercialization specialists with >60 years of combined experience.
Feel the Oligo Factory difference for your next scientific discovery!
The Oligo Factory Difference
- High Purity Oligos: 80% to >95% purity based on customer specifications
- Unrivaled Speed: Production to delivery in 4-6 weeks
- Scale For Growth: 25 mgs to kilograms of oligos, delivered on-spec and on-time
- Customized Quality Offerings: RUO, GMP-like, and GMP production
- Expertise: >18 years experience in custom oligo synthesis
Get a Custom Quote Today
Address:
56 Boynton Rd, Holliston, MA 01746
Contact:
Phone: (508) 275-3561
Email: Info@oligofactory.com