Technology

Our Synthesis Makes The Difference.

Proprietary Oligo
Synthesis Equipment

Oligo Factory has developed proprietary oligo synthesis equipment optimized for synthesis at larger scales (10s of mgs to 100s of grams to kgs). Our synthesizer suite, the NANDA Series, features multiple monitoring modes, including colorimetric, gravimetric, and conductivity to ensure maximum control and feedback of the synthesizer.

Enhanced trityl monitor control and feedback system to accommodate different deprotection requirements for the specific monomers as well as lengthening deprotection times with longer oligos.

Gravimetric control to provide positive verification of the delivery of reagents ensuring built-in monitoring of critical reagents.

Precise control of costly chemicals which provides for better quality and cost-savings, not afforded by conventional synthesizers, which is passed on to our customers.

Advanced In-House Technology

Turbulent Flow

Our synthesizers use turbulent flow for reagent delivery rather than laminar flow. Turbulent flow is the preferred method to properly facilitate mixing during the synthesis reagent delivery. Our synthesizers use an in-house modified gear pump to achieve the optimal turbulent flow effect.

Proprietary Software

Every synthesizer is controlled by our proprietary Validate™ software which measures the delivery of critical reagents for a “closed loop” validation of operations, improving quality management and synthesis efficiency.

Enhanced Purification

Oligo Factory uses several industry approved purifications via HPLC – both reverse-phase and ion-exchange. We also develop in-house options per customer requirement to maximize yield and purity needs.

Advanced Manufacturing Facility

In 2023, we opened our advanced oligo manufacturing facility and headquarters in Holliston, MA. The new facility substantially increases production capacity and enables us to meet growing customer demand for high quality oligonucleotides at scale.